Core Rigor and Reproducibility (CCoRRe)

The mission of the ABRF Committee on Core Rigor and Reproducibility (CCoRRe) is to enable rigorous and reproducible research through support of shared scientific resources in advancing technology, education and communication. Core facilities support a significant portion of the research conducted at biomolecular research institutions, thus playing a critical role in achieving efficient use of research funds and broadening access to advanced skills, expertise and technologies. Shared scientific research resources generate the majority of research data at many institutions, so their role in maintaining necessary expertise and generating high quality data is considerable. CCoRRe efforts are focused on building educational resources, sharing critical best practice guidelines, and providing important tools to the core community that will impact rigor, reproducibility and transparency across the range of science and technology.

Questions or interest in joining an ABRF committee? Contact us

New:  CCoRRe Resources (April 2022 draft manuscript and links to templates, best practices)  

Scientific Rigor, Reproducibility, and Transparency enabled by the ABRF Research Groups

The ABRF Research Groups (RGs), represent expertise for an array of cutting-edge and established technology platforms, perform multicenter research studies to determine and communicate best practices and community-based standards. This review provides a summary of the contributions of the ABRF RGs to promote scientific rigor and reproducibility in Cores from the published literature, ABRF meetings, and ABRF RGs communications.

Core Lab Reproducibility Survey

There is strong interest across the ABRF community in the overall conduct of rigorous and reproducible science, as demonstrated by the response to a recent survey conducted by the CCoRRe (Knudtson et al, J Biomol Tech. 2019 Sep;30(3):36-44). The survey was designed to develop understanding of how NIH initiatives on advancing scientific rigor and reproducibility influenced current services and new technology development. In addition, the survey aimed to identify challenges related to the conduct of rigorous research, and opportunities for improvements, new practices and resources that can support the best core science. 243 individuals from 21 countries responded to the survey, and 53% of them identified as members of the ABRF. The majority of the survey respondents were core facility directors or managers (69%) and work in an academic setting (72%) in the United States (79%), representing a wide range of technologies. 

Learn more about the survey results:

See the article on the survey from the September 2019 issue of Instrument Business Outlook

Read the report in the ABRF Journal of Biomolecular Techniques

View the poster presented at ABRF2019 Annual Meeting in San Antonio Texas </assets/docs/ccorre_2019_poster_final.pdf>


CCoRRe Committee Membership

Andrew Ott, Northwestern University (Co-Chair)
Christopher Gregory, University of North Carolina School of Medicine (Co-Chair)
Patricia Basta, University of North Carolina at Chapel Hill
Sridar Chittur (Executive Board Liaison) - SUNY Albany
Kevin Knudtson, University of Iowa 
Susan Meyn, Vanderbilt University Medical Center
Sheenah Mische, NYU Langone Medical Center
Katia Sol-Church, University of Virginia
Caterina Strambio-De-Castillia, University of Massachusetts Medical School
Michael Sturges, Miltenyi Biotec
Doug Taatjes, University of Vermont
Frances Weis-Garcia, Memorial Sloan Kettering Cancer Center
Nicole (Amanda) White, Cincinnati Children's Hospital Research Foundation